HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl D-alaninate hydrochloride → (R)-2-[(7-Isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl D-alaninate hydrochloride | HCID 11182647 | — |
| Reactant | 1-Chloro-4-hydroxy-7-isopropoxy-isoquinoline-3-carboxylic acid | HCID 53870439 | — |
| Product | (R)-2-[(7-Isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]propionic acid | HCID 86595460 | — |
Reaction Steps
Analogously to Example A-56, 0.040 g of 7-isopropoxy-1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid were allowed to react with D-Alanine methyl ester hydrochloride. The intermediate ester product was hydrolyzed as in Example A-56 to give 0.042 g of a white solid: MS-(−)-ion, M−1=353.0 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278325B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5ce02ac794df488294ecb80c1c85e13c |
| Source note | uspto-grants-2012_10 |