Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | L-Alanine | HCID 5950 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 66712886 | HCID 66712886 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 66712928 | HCID 66712928 | — |
Reaction Steps
To a solution of 6.0 ml of 0.5 M sodium methoxide in methanol was added 100 mg of 4-Mercapto-7-phenoxy-isoquinoline-3-carboxylic acid methyl ester and 286 mg of L-alanine. The mixture was heated to 150° C. for 15 minutes using a CEM Discover microwave reactor. The resultant solution was acidified to pH 3 with 1 N HCl, diluted with 10 ml water, and extracted with 20 ml of ethyl acetate. The organic fraction was washed with brine, dried over anhydrous sodium sulfate, and concentrated to 114 mg of product; MS (−): m/z 369.07 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08278325B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-2430ff51117840b186dc3c2ed28ef580 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
