Isopropanol → HCID 131729976, compound

Participants

Reaction Conditions

Reaction Steps

Epichlorohydrin (122.4 g, 1.32 mol), 4-bromoresorcinol (25.0 g, 0.13 mol) and Isopropyl alcohol (100 g) were added to a 500 ml three-neck flask and warmed to 75° C. A solution of 22.2 g 50 wt % sodium hydroxide in water was added dropwise to the flask over 6 hours. The flask temperature was raised to 83° C. and held for an additional 2 hours. After the reaction, the solution was filtered and solvents were evaporated. Toluene was then added to the residual mass. The solids were filtered and the toluene was again removed, giving a light-brown oil. Further purification was conducted using vacuum distillation to give a clear liquid which crystallizes upon standing. 1H NMR (CDCl3): δppm 2.6-2.9 (4H), 3.3 (2H), 3.8-4.3 (4H), 6.3-7.4 (3H).

Provenance & Evidence