Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethyl 1-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylate | HCID 9865974 | — |
| Product | Regadenoson | HCID 219024 | — |
Reaction Steps
Compound 12 (0.05 mg, 0.12 mmol) was added to 4 mL methylamine (40% sol. in water). The mixture was heated at 65° C. for 24 h. After concentration in vacuo, the residue was purified using prep. TLC (10% MeOH:DCM). 1HNMR (CD3OD) δ2.90 (s, 3H), 3.78 (m, 1H), 3.91 (m, 1H), 4.13 (d, 1H), 4.34 (d, 1H), 4.64 (m, 1H), 6.06 (d, 1H), 8.11 (s, 1H), 8.38 (s, 1H), 9.05 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08278435B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-0436aeec127e46c4a502220cd385ac0c |
|---|
| Source note | uspto-grants-2012_10 |
|---|
