HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Benzotriazole-1-methanol → 2-(6-Bromopyridin-2-yl)-2-(1,1-dioxidothiomorpholin-4-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Benzotriazole-1-methanol | HCID 224169 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 4-[(6-Bromopyridin-2-yl)methyl]thiomorpholine 1,1-dioxide | HCID 58335258 | — |
| Product | 2-(6-Bromopyridin-2-yl)-2-(1,1-dioxidothiomorpholin-4-yl)ethanol | HCID 58335277 | — |
Reaction Steps
The title compound was prepared as described in Example 3, Step 1 using 4-[(6-bromopyridin-2-yl)methyl]thiomorpholine 1,1-dioxide (2.94 g, 9.63 mmol), 1H-1,2,3-benzotriazol-1-ylmethanol (2.87, 19.17 mmol), and LDA (16 mL of 1.8 M in tetrahydrofuran/heptane/ethylbenzene) as starting materials. LRMS (APCI) calcd for C11H16BrN2O3S [M+H]+: 335.0, Found: 334.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278335B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-09984169836f4135b9e85f647d5346a7 |
| Source note | uspto-grants-2012_10 |