2-Methyl-2-butanol → Ethyl 5-{[6-(2-hydroxy-1-morpholin-4-ylethyl)pyridin-2-yl]amino}-2-(6-morpholin-4-ylpyridin-3-yl)-1,3-thiazole-4-carboxylate

Participants

Reaction Steps

The title compound was prepared as described in Example 3, Step 1 using ethyl 5-amino-2-(6-morpholin-4-ylpyridin-3-yl)-1,3-thiazole-4-carboxylate (114 mg, 0.34 mmol), 2-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanol (Example 3, Step 1) (98 mg, 0.34 mmol), Pd2(dba)3 (9.4 mg, 10.2 μmol), X-PHOS (24.4 mg, 0.051 mmol), potassium carbonate (51.8 mg, 0.38 mmol), and tert-amyl alcohol (1.7 ml) as starting materials. LRMS (APCI) calc'd for (C26H33N6O5S) [M+H]+, 541.2; found 541.1.

Provenance & Evidence