HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 4-Bromo-1-(diethoxymethyl)-2-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 4-Bromo-2-fluorobenzaldehyde | HCID 143517 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Product | 4-Bromo-1-(diethoxymethyl)-2-fluorobenzene | HCID 58335261 | — |
Reaction Steps
The title compound was prepared as described in Example 15, Step 2 using 4-bromo-2-fluorobenzaldehyde (102 g, 0.5 mol), triethylorthoformate (88.8 g, 0.6 mol), and PPTS (2.52 g, 0.05 mol) as starting materials. 1H NMR (400 MHz, CDCl3): δ 7.41 (d, 1H), 7.21 (d, 1H), 7.14 (d, 1H), 5.60 (s, 1H), 3.68 (q, 2H), 3.49 (q, 2H), 1.17 (t, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278335B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-52202d2d49f7475ab24a8df44620e158 |
| Source note | uspto-grants-2012_10 |