Sec-Butylamine → 2H-Cyclopenta[c]pyridine

Participants

Reaction Steps

Baldrinal (2) (1.1 g) was reacted with 2.5 g of sec-butylamine. After stirring for 10 minutes at room temperature, color changes from yellow to orange. When all the baldrinal was reacted, the excess amine was removed by rotary evaporation. After column chromatography with 8:3 hexanes:ethyl acetate as solvent, 15.7 mg of cyclopenta[c]pyridine (3) was collected.

Provenance & Evidence