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2,4-Dichloropyridine → 6-(2-Chloropyridin-4-yloxy)pyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichloropyridine | HCID 33515 | — |
| 反応物 | HCID 178507770 | HCID 178507770 | — |
| 生成物 | 6-(2-Chloropyridin-4-yloxy)pyridin-3-amine | HCID 86641691 | 35% |
反応手順
Using a procedure analogous to Example A1, 5-amino-2-hydroxypyridine (10.15 g, 92 mmol) and 2,4-dichloropyridine (13.64 g, 92 mmol) were combined to provide 6-(2-chloropyridin-4-yloxy)pyridin-3-amine (7.09 g, 35% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.12 (m, 1H), 7.61 (m, 1H), 7.26 (m, 1H), 7.0 (s, 1H), 6.97-6.94 (m, 2H), 5.4 (brs, 2H); MS (ESI) m/z: 222.0 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08278331B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-24cc2b78a5ab465ea6b917864440c000 |
| 出典メモ | uspto-grants-2012_10 |