HCID 57504912, compound → HCID 57504913, compound

Participants

Reaction Steps

A mixture of 1-benzyl-5-(tert-butyldimethylsilyloxy)-6a-(3′-methoxybiphenyl-3-yl)hexahydro-1H-cyclopenta[c]isoxazole (2.04 g, 3.76 mmol) and palladium on carbon (0.400 g) in acetic acid (10 mL) is stirred at room temperature under hydrogen atmosphere (50 psi) for 19 hours. The reaction is filtered through a pad of diatomaceous earth and the filter cake is washed with methanol three times and the filtrate is concentrated under reduced pressure. The residue is dissolved in dichloromethane, the pH adjusted to pH 12 by addition of saturated aqueous sodium bicarbonate, and is extracted three times with dichloromethane. The combined organic layers are dried over sodium sulfate, filtered, and concentrated under reduced pressure to give the title compound. ES/MS m/e: 428 (M+1).

Provenance & Evidence