Potassium Carbonate → HCID 59401308, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-[(3-methylbutylamino)methyl]naphthalen-1-ol (Preparation 14) (85 mg, 0.35 mmol) in DMF (10 mL), was added 6-chloronicotinonitrile (43 mg, 0.62 mmol) and K2CO3 (86 mg, 0.62 mmol). The reaction mixture was heated at 70° C. for 16 h. Solvent was removed in vacuo and residue partitioned between EtOAc (50 mL) and water (20 mL). The aqueous phase was extracted with EtOAc (50 mL) and the organic phase washed with NaHCO3 (20 mL), brine (20 mL) and dried (MgSO4). Solvent was removed in vacuo and the residue purified by column chromatography (DCM:MeOH:NH4OH, 95:5:0.5) to give the title compound: RT=2.83 min; m/z (ES+)=346.0 [M+H]+.

Provenance & Evidence