反应详情

温度

70 °C

To a solution of 6-(5-methylnaphthalen-1-yloxy)nicotinonitrile (Preparation 22) (530 mg, 2.04 mmol) in carbon tetrachloride (30 mL) under argon was added N-bromosuccinimide (435 mg, 2.44 mmol) followed by benzoyl peroxide (25 mg, 0.1 mmol). The mixture was heated to 70° C. for 16 h. The reaction mixture was cooled, filtered through celite, and washed with DCM (70 mL). The organic phase was washed with NaHCO3 (30 mL), brine (30 mL) and dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT=3.93 min; m/z (ES+)=341.0 [M+H]+.

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered through celite
3. washwashed with DCM (70 mL)
4. washThe organic phase was washed with NaHCO3 (30 mL), brine (30 mL)
5. dry with materialdried (MgSO4)
6. customSolvent was removed in vacuo