Potassium Carbonate → HCID 59401299, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-hydroxymethylnaphthalen-1-ol (Preparation 32) (350 mg, 2.01 mmol) and 3,4-difluorobenzonitrile (279 mg, 2.01 mmol) in sulfalone (8 mL) was added K2CO3 (1.39 g, 10.05 mmol) and the mixture heated to 80° C. for 16 h before cooling to rt. The mixture was partitioned between water (50 mL) and EtOAc (3×50 mL), the organic phase was washed with water (3×50 mL), brine (50 mL) and dried (MgSO4). Solvent was removed in vacuo and the residue purified by column chromatography (SiO2, MeOH:DCM, 2:98) to give the title compound: RT=3.54 min; m/z (ES+)=276.1 [M H2O]+.

Provenance & Evidence