3,4-Difluorobenzonitrile → HCID 59401290, compound

HRID 2060868Notes

Reaction equation

HRID 2060868 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][N:3]=1.[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1F)[C:17]#[N:18]>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][C:21]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][C:14]=2[F:13])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 5872033,4-DifluorobenzonitrileHCID 42818821-Chloro-4-hydroxyisoquinoline

Product 1

HCID 59401290HCID 59401290, compound

Procedure

Using the procedure outlined in Preparation 17, 1-chloro-4-hydroxyisoquinoline and 3,4-difluorobenzonitrile were converted to the title compound: RT=3.90 min; m/z (ES+)=299.04 [M+H]+.

Sources & evidence

ORD record
ord-3517beb7e56c45c59c938b141211a90b
Source dataset
uspto-grants-2012_10
Patent number
US08278442B2

Reaction notes

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