HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2060875Generated: November 1, 2026
Water → 6-((5-Formylquinolin-8-yl)oxy)nicotinonitrile
https://huagongshe.com/reaction/2060875
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Hydroxyquinoline-5-carbaldehyde | HCID 275363 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 6-((5-Formylquinolin-8-yl)oxy)nicotinonitrile | HCID 59401340 | — |
Reaction Steps
To a solution of 8-hydroxyquinoline-5-carbaldehyde (692 mg, 4 mmol) in sulfolane (8 mL) was added 2-chloro-5-cyanopyridine (552 mg, 4 mmol) and K2CO3 (1.7 g, 12 mmol). The reaction was heated at 90° C. for 2 h in a microwave. The reaction was cooled to rt and poured into water (100 mL). The resulting solid was filtered, washed with water, ether and air dried to give the title compound: RT=3.02 min; m/z (ES+)=276.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08278442B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-13cb8150562e4fca82b760fcbc563d26 |
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| Source note | uspto-grants-2012_10 |
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