HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2060878Generated: November 1, 2026
Potassium Carbonate → 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile
https://huagongshe.com/reaction/2060878
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Reactant | 7-Hydroxybenzo[b]thiophene-4-carbaldehyde | HCID 59401350 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile | HCID 59401361 | — |
Reaction Steps
A suspension of 7-hydroxybenzo[b]thiophene-4-carbaldehyde (Preparation 69) (100 mg, 0.62 mmol), 6-chloronicotinonitrile (86 mg, 0.62 mmol) and K2CO3 (258 mg, 1.87 mmol) in sulfolane (3 mL) was heated in a microwave reactor at 130 W/80° C. for 4 h. The mixture was cooled, poured onto ice water and the resulting solid filtered and air-dried to give the title compound: RT=3.40 min; m/z (ES+)=265.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08278442B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-11d83db49da44793b4e419b4065382ca |
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| Source note | uspto-grants-2012_10 |
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