HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile | HCID 59401361 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinamide | HCID 59401381 | — |
Reaction Steps
6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile (Preparation 70) (111 mg, 0.42 mmol) was added to K2CO3 (29 mg, 0.21 mmol) in DMSO (3 mL) followed by H2O2 solution (0.42 mL, 0.42 mmol). After 3 h water was added and the resulting solid filtered and air-dried to give the title compound: RT=2.93 min; m/z (ES+)=283.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278442B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ff27da153eb447ad834d716f7c7082de |
| Source note | uspto-grants-2012_10 |