6,7-Difluoro-3,3a,4,8b-tetrahydroindeno[2,1-d]oxazol-2-one → HCID 19699366, compound

HRID 2060886Notes

Reaction equation

HRID 2060886 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:11](=[CH:12][C:13]=1[F:14])[CH:10]1[CH:6]([NH:7]C(=O)O1)[CH2:5]2>[Pd].CCO>[F:1][C:2]1[CH:3]=[C:4]2[C:11](=[CH:12][C:13]=1[F:14])[CH2:10][CH:6]([NH2:7])[CH2:5]2

Participants

4

Reactant 1

HCID 594013946,7-Difluoro-3,3a,4,8b-tetrahydroindeno[2,1-d]oxazol-2-one

Product 1

HCID 19699366HCID 19699366, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 6,7-difluoro-3,3a,4,8b-tetrahydroindeno[2,1-d]oxazol-2-one (Preparation 80) (145 mg, 0.69 mmol) and 10% palladium on carbon (15 mg) in EtOH (10 mL) was stirred under H2 for 1 h. The reaction mixture was filtered through celite and the solvent removed in vacuo to give the title compound: δH (CDCl3) 2.66 (2H, dd), 3.15 (2H, dd), 3.86-3.94 (1H, m), 7.00 (2H, t).

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-8881b0ab66b046c1bd90eb411d168d0e
Source dataset
uspto-grants-2012_10
Patent number
US08278442B2

Reaction notes

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