Potassium Carbonate → HCID 59401310, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-hydroxy-1-naphthaldehyde (500 mg, 2.9 mmol) and 2-chloro-4-cyanopyridine (402 mg, 2.9 mmol) in DMF (4 mL) was added K2CO3 (2.01 g, 14.52 mmol). The reaction was heated for 1 h at 70° C. in a microwave. The mixture was diluted with EtOAc (100 mL), washed with water (2×50 mL) and the aqueous phase extracted with EtOAc (2×50 mL). The organic phase was washed with water (100 mL), 1M NaOH (3×60 mL), brine (50 mL) and dried (MgSO4). Solvent was removed in vacuo and the residue purified by column chromatography (SiO2, NH4OH:MeOH:DCM, 0.2:2:98) to give the title compound: RT=3.02 min; m/z (ES+)=293.1 [M+H]+.

Provenance & Evidence