2-Aminoindan hydrochloride → HCID 25121831, compound

HRID 2060902Notes

Reaction equation

HRID 2060902 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH:22]=O)=[N:14][CH:13]=1)[C:5]([NH2:7])=[O:6].Cl.[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH:26]1[NH2:34]>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH2:22][NH:34][CH:26]2[CH2:27][C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:25]2)=[N:14][CH:13]=1)[C:5]([NH2:7])=[O:6]

Participants

3

Reactant 2

HCID 1227642-Aminoindan hydrochlorideHCID 59401336HCID 59401336, compound

Product 1

HCID 25121831HCID 25121831, compound

Procedure

Using the procedure outlined in Example 100, 3-fluoro-4-(1-formylisoquinolin-4-yloxy)benzamide (Preparation 42) and indan-2-ylamine hydrochloride were converted to the title compound: RT=2.87 min; m/z (ES+)=428.1 [M+H]+.

Sources & evidence

ORD record
ord-a885fe24520d4bffb3152d1f5462f3f5
Source dataset
uspto-grants-2012_10
Patent number
US08278442B2

Reaction notes

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