HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-chloropyridin-2-amine → 3-(3-Bromo-5-chloro-pyridin-2-ylamino)-5-chloro-1-(4-methoxy-benzyl)-1H-pyrazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-chloropyridin-2-amine | HCID 2763971 | — |
| Reactant | 1-(4-methoxybenzyl)-3,5-dichloropyrazine-2(1H)-one | HCID 15498463 | — |
| Product | 3-(3-Bromo-5-chloro-pyridin-2-ylamino)-5-chloro-1-(4-methoxy-benzyl)-1H-pyrazin-2-one | HCID 16123545 | 58% |
Reaction Steps
The title compound was prepared in 58% yield from 2-amino-3-bromo-5-chloropyridine and 3,5-dichloro-1-(4-methoxy-benzyl)-1H-pyrazin-2-one in a manner analogous to that for the preparation of Compound 26. 1H NMR (400 MHz, DMSO-d6): δ 9.58 (s, 1H), 8.51 (d, 1H, J=2.4 Hz), 8.40 (d, 1H, J=2.4 Hz), 7.51 (s, 1H), 7.36 (d, 2H, J=8.8 Hz), 6.92 (d, 2H, J=8.8 Hz), 5.00 (s, 2H), 3.73 (s, 3H). MS (ES) [m+H] calc'd for C17H13BrCl2N4O2, 455, 457, 459; found 455, 457, 459.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278450B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-176ef90bc2934672b64a25fa136eed04 |
| Source note | uspto-grants-2012_10 |