3-(Dimethylamino)-1-propanol → HCID 57741411, compound

HRID 2060920Notes

Reaction equation

HRID 2060920 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.[CH3:10][N:11]([CH3:16])[CH2:12][CH2:13][CH2:14]O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[CH3:10])=[C:4]([I:9])[CH:3]=1

Participants

3

Reactant 2

HCID 766463-(Dimethylamino)-1-propanolHCID 6202344-Chloro-2-iodophenol

Product 1

HCID 57741411HCID 57741411, compound

Procedure

The title compound was synthesized using 4-chloro-2-iodophenol and 3-(dimethylamino)propan-1-ol, in an analogous procedure to that outlined in the preparation of Compound 174. 1H NMR (400 MHz, CDCl3) δ ppm 1.99-2.15 (m, 2H) 2.38 (s, 6H) 2.67 (t, J=7.33 Hz, 2H) 4.07 (t, J=6.06 Hz, 2H) 6.73 (d, J=8.84 Hz, 1H) 7.25 (d, J=2.53 Hz, 1H) 7.74 (d, J=2.53 Hz, 1H). [M+H] calc'd for C11H16Cl1NO, 339.99; found, 340.2.

Sources & evidence

ORD record
ord-1fbd72271d9845cdbbcfd3a8321e3ca4
Source dataset
uspto-grants-2012_10
Patent number
US08278450B2

Reaction notes

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