Potassium Iodide → HCID 68650236, compound

Participants

Reaction Steps

A mixture of 5,7-diBOC-2,10-difluoro-6-(2-bromoethoxy)indolo[2,3-b]carbazole (150.0 mg, 0.24 mmol), tert-butyl 4-(2-hydroxyethyl)-1,4-diazepane-1-carboxylate (97.6 mg, 0.49 mmol), a base (K2CO3 or Cs2CO3; 2-10 equiv) and potassium iodide (0.1 equivalent) in a anhydrous solvent (DMF, MeCN or DMSO; 30 mL per mmol) was heated to 80-90° C. for 1-2 hours. The reaction was cooled to room temperature and filtered. The solution was concentrated and dried under vacuum pump. The residue was purified by flash chromatography to provide the 6-(2-(1,4-diazepan-1-yl)ethoxy)-2,10-difluoro-5,7-diBOC-indolo[2,3-b]carbazole.

Provenance & Evidence