Trifluoroacetic acid → HCID 59238943, compound

Participants

Reaction Steps

The title compound was prepared by the reaction tert-butyl 12-bromo-2,10-difluoro-6-methoxyindolo[2,3-b]carbazole-5(7H)-carboxylate with pyrrolidine in the presence of Pd(OAc)2, BINAP, and NaOtBu at 80° C. for 2 h, followed deprotection with TFA. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.29 (s, 2H), 7.70 (dd, J=10.0, 2.4 Hz, 2H), 7.43 (dd, J=8.8, 4.8 Hz, 2H), 7.19 (td, J=9.2, 2.4 Hz, 2H), 4.05 (s, 3H), 3.43-3.55 (m, 4H), 2.40-2.30 (m, 4H).

Provenance & Evidence