Hydrochloric Acid → HCID 59498061, compound

Participants

Reaction Steps

To a solution of 1.83 g (4.59 mmol) of phenyl 2,3-dibromo-2-methyl-N-phenylpropanimidate in 10 ml of THF was added 770 mg (5.05 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene and stirred at room temperature for 2 hours. To the mixture was added 1N HCl and extracted with tert-butyl methyl ether. The combined organic layer was washed sequentially with a saturated aqueous NaHCO3 solution and a saturated NaCl solution, dried over anhydrous MgSO4, and then concentrated under vacuum. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=20/1) to obtain 1.26 g of phenyl 3-bromo-2-methyl-N-phenyl-2-propenimidate.

Provenance & Evidence