Tert-Butyl hypochlorite → HCID 46198850, compound

Participants

Reaction Steps

A solution of 2-(4-(2-aminopropan-2-yl)-1H-1,2,3-triazol-1-yl)-N,N,N-trimethylethanaminium hydrochloride (1.45 g, 5.8 mmol) in methanol (100 ml) was stirred at room temperature. t-Butyl hypochlorite (1.90 g, 17.5 mmol) was added to the mixture, and the combined mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated in vacuo, and purified by prep-HPLC to give 769 mg (42% yield) of 2-(4-(2-(dichloroamino)propan-2-yl)-1H-1,2,3-triazol-1-yl)-N,N,N-trimethylethanaminium chloride. 1H NMR (D2O) δ 8.41 (s, 1 H), 5.10 (t, J=4.7, 2 H), 4.06 (t, J=4.7, 2 H), 3.18 (s, 9 H), 1.83 (s, 6H); MS (ESI+) calculated for C10H20Cl2N5+: 280.11. Found: 280.1 (M+).

Provenance & Evidence