1,1'-Carbonyldiimidazole → N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-1H-imidazole-1-carboxamide

Participants

Reaction Steps

To a solution of 3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one 15 (22 mg, 0.08 mmol) in ACN (0.5 mL) was added CDI (16 mg, 0.09 mmol). After stirring at rt for 2 h, solvent was removed and the crude N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-1H-imidazole-1-carboxamide 18 was used without further purification. MS m/z 374.3 (M+1).

Provenance & Evidence