p-Toluenesulfonic acid → HCID 44201106, compound

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Reaction Steps

3-(5-Amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one 15 (30 mg, 0.107 mmol), 3-chloro-5-phenyl-1,2,4-thiadiazole (41 mg, 0.21 mmol) and TsOH (10 mg) were heated at 100° C. in dioxane (2 ml). After 10 h, the solution was cooled and filtered. The mixture was purified by preparative LC/MS to give 1,7-dimethyl-3-(2-methyl-5-(5-phenyl-1,2,4-thiadiazol-3-ylamino)phenyl)-1,6-naphthyridin-2(1H)-one (G1). MS m/z 440.5 (M+1).

Provenance & Evidence