HCID 131727223, compound → HCID 131727224, compound

HRID 2061208Notes

Reaction equation

HRID 2061208 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:21][CH2:20][N:19]([C:22](=[O:33])[CH2:23][NH:24][C:25]([CH2:27][C@H:28]4[CH2:30][C:29]4([CH3:32])[CH3:31])=[O:26])[CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1>C(O)C.[H][H].[C].[Pd]>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:17][CH2:18][N:19]([C:22](=[O:33])[CH2:23][NH:24][C:25]([CH2:27][C@H:28]4[CH2:30][C:29]4([CH3:31])[CH3:32])=[O:26])[CH2:20][CH2:21]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 1

HCID 131727223HCID 131727223, compound

Product 1

HCID 131727224HCID 131727224, compound

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

72.8 mg of palladium carbon (10% w/v) was added to 72.8 mg (0.171 mmol) of (1R)—N-{2-[4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-piperidinyl]-2-oxoethyl}-2,2-dimethylcyclopropanecarboxyamide in 10 ml of ethanol, and they were stirred at 4.0 MPa in hydrogen gas atmosphere overnight. After the filtration, the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. filtrationAfter the filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-256a931e300e4a1eac1e0a352db54baf
Source dataset
uspto-grants-2012_10
Patent number
US08278329B2

Reaction notes

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