Triethyl Phosphate → 1-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)-3-phenylurea

HRID 2061296Notes

Reaction equation

HRID 2061296 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[C:9]1[S:10][C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[N:13]=1.P(OCC)(OCC)(OCC)=O.[C:29]1([N:35]=[C:36]=[O:37])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[S:10]1[C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[N:13]=[C:9]1[C:3]1[CH:4]=[C:5]([NH:8][C:36]([NH:35][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:37])[CH:6]=[CH:7][C:2]=1[OH:1]

Participants

4

Reactant 3

HCID 6535Triethyl PhosphateHCID 7672Phenyl isocyanateHCID 7386584-Amino-2-benzothiazol-2-yl-phenol

Product 1

HCID 1357420051-(3-(benzo[d]thiazol-2-yl)-4-hydroxyphenyl)-3-phenylurea

Procedure

The procedure to prepare this compound was the same as that described for preparing the compound of Example 5 except that 1 gram of the 2-(2′-hydroxy-5′-aminophenyl)benzothiazole compound (prepared in Step B of Example 5), 18.6 g of triethyl phosphate and 0.55 g of phenyl isocyanate were used. The desired compound of Formula (VII) was obtained in a yield of 0.76 g.

Workup

  1. customThe procedure to prepare this compound

Sources & evidence

ORD record
ord-670ee2dad7614d8eae929e912c6a2101
Source dataset
uspto-grants-2012_10
Patent number
US08283015B2

Reaction notes

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