Imidazole → HCID 59621119, compound

Participants

Reaction Steps

To an ice cooled solution of 4-(5-iodo-2-methyl-benzyl)phenol (12.0 g) and imidazole (3.2 g) in dimethylformamide (40 mL) is added tert-butyldimethyl-chlorosilane (6.1 g). The ice-bath is removed and the solution is stirred at ambient temperature overnight. The solution is diluted with ethyl acetate and washed twice with hydrochloric acid (1 mol/L). The organic phase is dried (sodium sulphate) and concentrated in vacuo. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:0->20:1).

Provenance & Evidence