反应详情

温度

0 °C

Compound 29 (450 mg, 2.56 mmol) was dissolved in EtOH (10 mL). NaBH4 (104 mg, 2.81 mmol) was added portionwise at 0° C., with vigorous stirring. The suspension was stirred at 0° C. for 15 min and then at room temperature for 1.5 h. Solvent was evaporated off in-vacuo. The resulting crude alcohol residue was dissolved in toluene (5 mL) and the solution was cooled to 0° C. PBr3 (240 μL, 2.56 mmol) was added dropwise over 10 min.

1. waitat room temperature for 1.5 h
2. customSolvent was evaporated off in-vacuo
3. dissolutionThe resulting crude alcohol residue was dissolved in toluene (5 mL)
4. temperaturethe solution was cooled to 0° C