反应详情

温度

0 °C

1-(Naphthalen-2-yl)ethanol (2.0 g, 11.6 mmol) was dissolved in toluene (30 mL). The solution was cooled to 0° C. PBr3 (1.09 mL, 11.6 mmol) was added dropwise over 15 min. The reaction mixture was then brought up to room temperature and stirred for 1 h. The mixture was washed with K2CO3 solution and extracted with EtOAc (3×30 mL). The EtOAc layer was washed with brine and dried (MgSO4). The solvent was evaporated off in-vacuo to give crude 2-(1-bromoethyl)naphthalene. This intermediate was used in the following step.

1. customwas then brought up to room temperature
2. washThe mixture was washed with K2CO3 solution
3. extractionextracted with EtOAc (3×30 mL)
4. washThe EtOAc layer was washed with brine
5. dry with materialdried (MgSO4)
6. customThe solvent was evaporated off in-vacuo