HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → 1-Bromo-5-chloro-3-fluoro-2-isocyanatobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 2-Bromo-4-chloro-6-fluoroaniline | HCID 2736222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Bromo-5-chloro-3-fluoro-2-isocyanatobenzene | HCID 86618941 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2-Bromo-4-chloro-6-fluoroaniline (5 mmol, 1.125 g), bis(trichloromethyl) carbonate (1.7 mmol, 0.50 g) and 1,4-dioxane (10 ml) were mixed together and the mixture was heated to 100° C. for 15 minutes; the mixture was then cooled to room temperature and it was filtered. The filtrate was concentrated to afford a mixture of products (2.2 g) containing the title compound, M++MeO=283 (LC-MS run in methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283364B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-260a82b4583142db8ad40dc55e3ce1fe |
| Source note | uspto-grants-2012_10 |