HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl 4-[(5-cyclopropyl-3-fluoro-2-nitrophenyl)amino]-1-piperidinecarboxylate → 1,1-Dimethylethyl 4-[(2-amino-5-cyclopropyl-3-fluorophenyl)amino]-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl 4-[(5-cyclopropyl-3-fluoro-2-nitrophenyl)amino]-1-piperidinecarboxylate | HCID 59683270 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,1-Dimethylethyl 4-[(2-amino-5-cyclopropyl-3-fluorophenyl)amino]-1-piperidinecarboxylate | HCID 59683265 | 100.2% |
Reaction Steps
1,1-Dimethylethyl 4-[(5-cyclopropyl-3-fluoro-2-nitrophenyl)amino]-1-piperidinecarboxylate (D26, 0.8 mmol, 300 mg) was dissolved in MeOH (15 ml) and it was reduced by THALIS H-CUBE apparatus (bought from Asynt) using a palladium cartridge. The process yielded 280 mgs of the title compound, complete conversion, M+−COOC(CH3)3=250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283364B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b1f2ee58120e40368447accff39618bc |
| Source note | uspto-grants-2012_10 |