HCID 67294316, compound → HCID 86656079, compound

Participants

Reaction Steps

(4-fluorophenyl)(8-(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanone (total yield from step 1d) was added to 200 mL of CHCl3 and 15 g MnO2. The resulting suspension was refluxed for 4 h to completion. MnO2 was then removed by filtration through CELITE® (a diatomite filter) and washed 2× with CHCl3. Evaporation of the solvent gave 5 g of crude product which was used without further purification.

Provenance & Evidence