1H-Indole-5-methanamine, 2-(trifluoromethyl)-, hydrochloride (1:1) → HCID 44255925, compound

HRID 2061572Notes

Reaction equation

HRID 2061572 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([F:24])([F:23])[F:22])=[CH:15]3)=[O:9])[CH:5]=[CH:4][CH:3]=1.Cl.FC(F)(F)[C:28]1[NH:29]C2C(C=1)=CC(CN)=CC=2>>[C:2]([C:3]1[N:29]=[CH:28][C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([F:24])([F:23])[F:22])=[CH:15]3)=[O:9])=[CH:5][CH:4]=1)#[N:7]

Participants

3

Reactant 2

HCID 669093631H-Indole-5-methanamine, 2-(trifluoromethyl)-, hydrochloride (1:1)2×HCID 86761631HCID 86761631, compound

Product 1

HCID 44255925HCID 44255925, compound

Procedure

The title compound was prepared by a similar procedure to that described for Compound 3 using the appropriate carboxylic acid with 2-(trifluoromethyl)-1H-indol-5-yl]methyl}amine hydrochloride (Intermediate 5):

Sources & evidence

ORD record
ord-dab70edecfd048e89699527ab537c66c
Source dataset
uspto-grants-2012_10
Patent number
US08283365B2

Reaction notes

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