tert-Butoxy bis(dimethylamino)methane → HCID 67303209, compound

HRID 2061591Notes

Reaction equation

HRID 2061591 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH:17]3[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[CH:13]2[CH2:14][C:15](=[O:24])[CH2:16]3)(=[O:11])=[O:10])=[CH:5][CH:4]=1.CC(O[CH:32](N(C)C)[N:33]([CH3:35])[CH3:34])(C)C>>[CH3:32][N:33]([CH:35]=[C:14]1[C:15](=[O:24])[CH2:16][CH:17]2[N:12]([S:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:1])([F:25])[F:26])=[CH:4][CH:5]=3)(=[O:10])=[O:11])[CH:13]1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=12)[CH3:34]

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 59268912HCID 59268912, compound

Product 1

HCID 67303209HCID 67303209, compound

Procedure

Compound 16 (15 mg, 0.04 mmol) was mixed with 0.3 mL of Bredereck's reagent and the mixture was stirred at room temperature for 30 min. The reaction was quenched with water (1 mL) and extracted with EtOAc. After evaporation of the solvent, the crude product was obtained as a yellow oil and used without further purification.

Workup

  1. customThe reaction was quenched with water (1 mL)
  2. extractionextracted with EtOAc
  3. customAfter evaporation of the solvent

Sources & evidence

ORD record
ord-d18b1807e7c24e068a9a2a8609a0927c
Source dataset
uspto-grants-2012_10
Patent number
US08283358B2

Reaction notes

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