Lithium borohydride → HCID 67303821, compound

Participants

Reaction Steps

Lithium borohydride (10 mg, 0.516 mmol) was added to a solution of ethyl 1,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazole-6-carboxylate and ethyl 2,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-2H-4,8-epiminocycloocta[c]pyrazole-6-carboxylate (57) (0.151 mg, 0.258 mmol) in THF (1 mL) and the resulting solution was stirred at room temperature for 2 h. The reaction mixture was diluted with EtOAc and washed with water. The organic phase was dried (Na2SO4), filtered and concentrated to give {1,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazol-6-yl}methanol and {2,10-Bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-2H-4,8-epiminocycloocta[c]pyrazol-6-yl}methanol (58). MS (ESI) 542.0 (M+H).

Provenance & Evidence