Triethylamine → HCID 67303576, compound

Participants

Reaction Steps

Methanesulfonyl chloride (30 μL, 0.390 mmol) and triethylamine (162 μL, 1.17 mmol) were added to a solution of 1-{1,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazol-6-yl}-N-hydroxymethanimine and 1-{2,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazol-6-yl}-N-hydroxymethanimine (60) (73 mg, 0.130 mmol) in CH2Cl2 (1 mL) and the resulting solution was stirred at room temperature for 0.5 h. The reaction mixture was diluted with CH2Cl2 and washed with saturated aqueous NaHCO3. The organic phase was dried (Na2SO4), filtered, and concentrated to give 1,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazole-6-carbonitrile and 2,10-bis[(4-chlorophenyl)sulfonyl]-4,5,6,7,8,9-hexahydro-2H-4,8-epiminocycloocta[c]pyrazole-6-carbonitrile (61). MS (ESI) 537.0 (M+H).

Provenance & Evidence