참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 3,6-Dibromo-2-(dibromomethyl)pyridine | HCID 59268900 | — |
| 촉매 | Silver Nitrate | HCID 24470 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3,6-Dibromopyridine-2-carbaldehyde | HCID 59268909 | — |
반응 단계
A solution of silver nitrate (8.5 g, 50 mmol) in water (26 mL) was added dropwise to a solution of compound 84 (8.17 g, 20 mmol) in refluxing EtOH (100 mL). The mixture was stirred at 80° C. for 5 hours. After the mixture was cooled to room temperature, it was diluted with water (100 mL), extracted with EtOAc (3×), dried over Na2SO4, filtered and concentrated under reduced pressure. The product was obtained after silica gel chromatography eluting with 0-40% EtOAc in hexane (2.85 g, 51% over two steps).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08283358B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-770831a3eb274f6183db94c0cbf2fca2 |
|---|
| 출처 메모 | uspto-grants-2012_10 |
|---|
