HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2061626Generated: November 2, 2026
Dimethylformamide dimethyl acetal → 7-Cyclopropyl-2-[(dimethylamino)methylidene]-8-{[4-(trifluoromethyl)phenyl]sulfonyl}-8-azabicyclo[3.2.1]oct-6-en-3-one
https://huagongshe.com/reaction/2061626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 6-Cyclopropyl-8-(4-(trifluoromethyl)phenylsulfonyl)-8-azabicyclo[3.2.1]oct-6-en-3-one | HCID 67303334 | — |
| Product | 7-Cyclopropyl-2-[(dimethylamino)methylidene]-8-{[4-(trifluoromethyl)phenyl]sulfonyl}-8-azabicyclo[3.2.1]oct-6-en-3-one | HCID 67302828 | — |
Reaction Steps
6-Cyclopropyl-8-(4-(trifluoromethyl)phenylsulfonyl)-8-azabicyclo[3.2.1]oct-6-en-3-one (1.02 g, 2.74 mmol), was dissolved in DMF-DMA (6 mL) and heated to 100° C. for 4 h. The reaction mixture was concentrated under vacuum to give compound 117. MS (ESI) 427.1 (M+H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08283358B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-67623a73e91d4909b96b39669ffa4376 |
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| Source note | uspto-grants-2012_10 |
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