2,6-Diisopropylphenyl isocyanate → 1-(2,6-Diisopropyl-phenyl)-3-[1-(toluene-4-sulfonyl)cyclopentylmethyl]-urea

HRID 2061645Notes

Reaction equation

HRID 2061645 reaction equation
[C:1]1([CH3:17])[CH:6]=[CH:5][C:4]([S:7]([C:10]2([CH2:15][NH2:16])[CH2:14][CH2:13][CH2:12][CH2:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[N:18]([C:21]1[C:26]([CH:27]([CH3:29])[CH3:28])=[CH:25][CH:24]=[CH:23][C:22]=1[CH:30]([CH3:32])[CH3:31])=[C:19]=[O:20]>>[CH:30]([C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([CH:27]([CH3:28])[CH3:29])[C:21]=1[NH:18][C:19]([NH:16][CH2:15][C:10]1([S:7]([C:4]2[CH:3]=[CH:2][C:1]([CH3:17])=[CH:6][CH:5]=2)(=[O:9])=[O:8])[CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:20])([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 922592,6-Diisopropylphenyl isocyanateHCID 68630538C-[1-(toluene-4-sulfonyl)-cyclopentyl]-methylamine

Product 1

HCID 252254821-(2,6-Diisopropyl-phenyl)-3-[1-(toluene-4-sulfonyl)cyclopentylmethyl]-ureaYield 77%

Procedure

Similarly to Example 1(c), by reaction of 200 mg (0.8 mmol) of C-[1-(toluene-4-sulfonyl)-cyclopentyl]-methylamine with 177 mg (0.87 mmol) of 2-isocyanato-1,3-diisopropyl-benzene. 276 mg of 1-(2,6-diisopropyl-phenyl)-3-[1-(toluene-4-sulfonyl)cyclopentylmethyl]-urea is obtained in the form of an off-white powder. (Yield=77%).

Sources & evidence

ORD record
ord-6e1f04efd4b1444e87bbd967c844c124
Source dataset
uspto-grants-2012_10
Patent number
US08283378B2

Reaction notes

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