HCID 10708125, compound → HCID 68631578, compound

HRID 2061647Notes

Reaction equation

HRID 2061647 reaction equation
[C:1]1([S:7]([C:10]2([C:19]#[N:20])[CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:1]1([S:7]([C:10]2([CH2:19][NH2:20])[CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:18]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 10708125HCID 10708125, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 68631578HCID 68631578, compoundYield 17%

Procedure

Similarly to Example 1(b), by reaction of 1 g (3.5 mmol) of 2-benzenesulfonyl-indane-2-carbonitrile with 161 mg (4.2 mmol) of lithium aluminum hydride. 168 mg of C-(2-benzenesulfonyl-indan-2-yl)-methylamine is obtained in the form of a brown oil. (Yield=17%).

Sources & evidence

ORD record
ord-59d04dfdc51b4bb1a1c80ae3df9b6d62
Source dataset
uspto-grants-2012_10
Patent number
US08283378B2

Reaction notes

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