Nitromethane → HCID 13956609, compound

Participants

Reaction Steps

1.05 ml (10 mmol) of cyclohexanone, 5.5 ml (101 mmol) of nitromethane, 2.1 ml (21 mmol) of piperidine are added to a solution of 5 ml (42 mmol) of benzylmercaptan in 20 ml of acetonitrile. The solution is refluxed for 4 h. At room temperature, the mixture is evaporated and the residue is chromatographed on silica gel (heptane then heptane/ethyl acetate, 50/50, v/v). 600 mg of (1-nitromethyl-cyclohexylsulfanylmethyl)-benzene is obtained in the form of a colorless oil. (Yield=22%).

Provenance & Evidence