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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2061681Generated: November 3, 2026

Ethylamine → (2R)-1-Benzyl-N-[4-(ethylamino)-3,4-dioxo-1-phenylbutan-2-yl]-5-oxopyrrolidine-2-carboxamide

https://huagongshe.com/reaction/2061681

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylamineHCID 6341—
ReactantNitrate(1-), oxo-HCID 3001380—
Reactant3-((R)-1-Benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoic AcidHCID 66644572—
ReactantHCID 178514248HCID 178514248—
Product(2R)-1-Benzyl-N-[4-(ethylamino)-3,4-dioxo-1-phenylbutan-2-yl]-5-oxopyrrolidine-2-carboxamideHCID 67094752—

Reaction Steps

Coupling of 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenyl-butanoic acid with ethylamine and oxidation of the resulting hydroxyamide intermediate to the corresponding ketoamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08283363B2
Source datasetuspto-grants-2012_10
ORD IDord-2c89a10ab4cc4886a25504d5c43ec9df
Source noteuspto-grants-2012_10