O-(cyclopropylmethyl)hydroxylamine → HCID 86652464, compound

HRID 2061698Notes

Reaction equation

HRID 2061698 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([NH:16][CH:17]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:18]([OH:22])[C:19](O)=[O:20])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:30]1([CH2:33][O:34][NH2:35])[CH2:32][CH2:31]1>>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C@@H:9]1[C:14]([NH:16][CH:17]([CH:18]([OH:22])[C:19]([NH:35][O:34][CH2:33][CH:30]1[CH2:32][CH2:31]1)=[O:20])[CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11182605O-(cyclopropylmethyl)hydroxylamineHCID 666445723-((R)-1-Benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoic Acid

Product 1

HCID 86652464HCID 86652464, compound

Procedure

The reaction can be carried out in analogy to reaction step 20.3 by reacting 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoic acid with O-(cyclopropylmethyl)hydroxylamine.

Workup

  1. customThe reaction
  2. customcan be carried out in analogy to reaction step 20.3

Sources & evidence

ORD record
ord-849b92a7496c438092edbc32288b9c4d
Source dataset
uspto-grants-2012_10
Patent number
US08283363B2

Reaction notes

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