HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → HCID 59416171, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59415783 | HCID 59415783 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59416171 | HCID 59416171 | 53.5% |
Reaction Steps
To a solution of 1-cyclopropyl-6-(6-(3-ethylureido)-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (Example 20, 80 mg, 0.15 mmol) in DMF (3 mL) was added HATU (112 mg, 0.29 mmol), DIEA (0.051 mL, 0.29 mmol) followed by 2-methoxyethanamine (22.11 mg, 0.29 mmol). After 1 h stirring, LC-MS shows completion of reaction. DMF removed under vacuum, and the residue was purified by ISCO column using MeOH—CH2Cl2 (0-20%) to give white solid (47.3 mg, 53.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08283361B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5658527f8b894d229a7ae346181f8fbc |
| Source note | uspto-grants-2012_10 |