Diethyl (ethoxymethylene)malonate → Diethyl 2-((3-iodophenylamino)methylene)malonate

Participants

Reaction Steps

A mixture of ethoxymethylene malonic acid diethyl ester (13.72 g, 0.068 mol) and 3-iodoaniline (15 g, 0.068 mole) in toluene (230 ml) was refluxed for 1 h. After this period of time, solvents were removed under vacuum, and the crude material was precipitated in methyl tert-butyl ether and the resulting white solid was filtered, and dried under vacuum (24.3 g, 93%).

Provenance & Evidence