反应详情

温度

80 °C

A suspension of 5-bromo-2-(3-propylureido)pyridine-4-carbothioamide (Intermediate 44, 100 g, 315 mmol), 3-bromo-1,1,1-trifluoroacetone (64 mL, 630 mmol) in acetonitrile (1.5 L) was heated at 80° C. for 20 hours. The solution was then cooled down and was concentrated under reduced pressure. This gave an orange oil that was carried on without further purification.

1. temperatureThe solution was then cooled down
2. concentrationwas concentrated under reduced pressure
3. customThis gave an orange oil that
4. customwas carried on without further purification